Interviewer: Thank you. Good afternoon, Zudin.
Zudin: Afternoon to you also. How are you?
Interviewer: I'm good. I hope you're enjoying the meeting so far.
Zudin: Amazing, so far.
Interviewer: Good. Zudin, a couple of questions. At our symposia, you had the excellent talk. What is important for us is really, can you summarize for us in really few sentences, what are the key messages that you want to really portray to the audience?
Zudin: The two real main messages are, one that our current nutritional interventions, the energy and the protein that we're giving our patients doesn't work as far as preserving muscle mass and we know biologically why this doesn't work. That's the first thing. We mustn't fool ourselves and to think that we are definitely helping people by giving people nutrition. The second thing is we need a- if you're like a frameshift, it's this [unintelligible 00:01:02] disruptive thinking to think about how we can generate better energy in our patients and how we can get protein into them at the right time and the right form so they can maintain muscle protein homeostasis.
Interviewer: This brings me to the next question where many of the clinicians give, now based on the guideline, high protein that leads to the beginning when they are in a catabolic state- the patients are in a catabolic state. Not having those patients moving or exercising, what happens to those protein and what do you suggest we should do?
Zudin: This is a very difficult one because those patients we're giving high protein concentrations to while acting on normal physiology. If he gave you and I have high levels of protein and we started doing some exercise, we'll build up muscle. These patients are not doing any exercise. We are trying to mobilize them and rehabilitate them but that's not the same as resistance exercise if we know they really struggle.
They can use that protein for muscle protein synthesis. One of two things is going to happen. It's going to get oxidized and wasted and it was a waste of time, or it's going to enter the urea cycle and generate toxins which are bad for the muscle. That actually is something we're really interested in and looking at that moment, trying to understand protein toxicity which is something-- I agree but other [unintelligible 00:02:31]
[00:02:32] [END OF AUDIO]